why is tirzepatide not working for me anymore Weight regain after stopping : r/tirzepatidecompound My patient has been on

Tirzepatide is a dual GIP/GLP-1 receptor agonist that works through a different mechanism and may cause fewer nausea symptoms in patients who don't tolerate semaglutide well

Siddiqi, S., Polly, T

Recent case reports and large case series have shown a risk of retained gastric contents and cases of pulmonary aspiration during sedation for endoscopic procedures or general anaesthesia in individuals treated with GLP-1RAs or GLP-1/GIPRAs

Consider adding electrolyte supplements or drinking electrolyte-enhanced water if GI symptoms persist

Long-term safety data beyond two years in large randomized trials is limited

These adverse effects were likely to be due to pre-existing factors i.e