Dipeptidyl peptidase IV inhibition upregulates GLUT4 translocation and expression in heart and skeletal muscle of spontaneously hypertensive rats
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Fehse F, Trautmann M, Holst JJ, Halseth AE, Nanayakkara N, Nielsen LL, Fineman MS, Kim DD, Nauck MA
That rise in cyclic AMP is the central second messenger of GLP-1 action, working through protein kinase A and the exchange protein Epac2 to drive the receptors downstream effects