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Could this really happen?' The scheming, sociopathic fourth grader - voiced by co-creator Trey Parker - has always been sensitive and in denial about his obesity, famously exclaiming: 'I'm not fat, I'm big-boned!' When a therapist dared to mock Cartman's weight in season 15 episode 'TMI' - he texted the psychiatrist's wife and implicated him in an affair with a 14-year-old girl, leading to the wife's suicide

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These gastrointestinal disturbances can indirectly contribute to feelings of tiredness and reduced energy

Diet, gut microbiota and immune responses

2016;6(2):e009389

Menzies, F