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Elevated ATF3 expression in aging osteocytes promotes iron uptake by upregulating TFR1 while inhibiting SLC7A11-mediated cystine uptake, leading to iron overload and lipid peroxidation, ultimately resulting in ferroptosis

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Once the peptide is no longer present in the body, the stimulation of pigment-producing cells reduces and, over time, normal skin turnover gradually diminishes the excess pigmentation, Dr

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