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Mounjaro Slow Titration for Sensitivity: A Clinical Guide to Tirzepatide Dose Escalation At a glance Starting dose / 2.5 mg subcutaneously once weekly for at least 4 weeks Standard step-up / increase by 2.5 mg every 4 weeks as tolerated Slow-titration step-up / increase by 2.5 mg every 8 to 12 weeks for sensitive patients Maximum approved dose / 15 mg once weekly Primary GI side effects / nausea (12 to 18%), diarrhea (13 to 17%), vomiting (6 to 9%) Key trial / SURPASS-2 (N=1,879) showed 15 mg tirzepatide produced 2.01% HbA1c reduction vs

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