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The combination of afamelanotide implant plus NB-UVB achieved 48.6% repigmentation at day 168, compared to 33.3% with NB-UVB monotherapy a statistically significant and clinically meaningful difference (Lim et al., 2015)

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The Ca 2+ released from the ER into the cytoplasm during signalling is rapidly reabsorbed in the ER lumen, with only a small fraction entering the mitochondria

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