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In clinical trials, both exenatide and lixisenatide reduced body weight by 2.03.8 kg and reduced HbA 1c levels by 0.51.5% (5.51.6 mmol/mol) [23,24,25]

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For comparison, tirzepatide before and after results in men show similar or greater reductions over comparable timeframes, as the dual-agonist mechanism targets both GLP-1 and GIP receptors simultaneously