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BioSpace / Annalee Armstrong Lilly's Retatrutide Scores Triple Trial Triumph With 26% Weight Loss, But New Safety Signal Emerges

In these STEP trials, most participants experienced mild to moderate symptoms, with the incidence of severe side effects being 9.8% in the semaglutide treatment group and 6.4% in the placebo group

In general, they couple the weight-reducing efficacy of glucagon-like peptide-1 receptor (GLP-1R), gastric inhibitory polypeptide receptor (GIP-R) and the glucagon receptor (GCGR) agonism while simultaneously buffering the glycemic effects of GCG with dual incretin receptor activation, according to a US National Institutes of Health website

There is no exact weight loss rate, and everyone may reach his or her goals differently

Safety and Side Effects Observed So Far Side effects reported in retatrutide trials were generally consistent with other incretin-based therapies, most commonly involving gastrointestinal symptoms

Glp1r expression in the liver is localized to CD8 and T cells