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The loss of bone mass can be overcome by estrogen add-back/hormone replacement therapy (Surrey, 2010) but this must be balanced to avoid estrogen action upon lesion survival and potential recurrence of disease and its symptomology

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The protocol for a 3mL vial: draw the desired BAC water volume into a sterile needle and syringe, inject slowly down the side of the vial (not directly onto the lyophilized cake), allow the cake to dissolve without agitation, then gently swirl (never vortex) to ensure complete dissolution