soul trial oral semaglutide cardiovascular outcomes 2025 align more closely with attained dose than achieved weight loss Projected reduction in major adverse

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Setoyama D, Lee HY, Moon JS, Tian J, Kang YE, Lee JH, et al

While all GLP-1 receptor agonists effectively lower hemoglobin A1c and promote weight loss, there are meaningful differences in their magnitude of effect, titration schedules, and adverse effect profiles that influence clinical decision-making