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However, reduced ERK (Extracellular signal-regulated kinases) phosphorylation in GNE deficient cells after IGF-1 treatment suggests downregulation of the ERK pathway

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doi: 10.1046/j.1528-1157.2001.18001.x 16

IGF-1 plays a key role in muscle cell growth, tissue repair, and anabolic signaling, making it central to performance and recovery research

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Rybelsus is approved for type 2 diabetes but not for weight loss, which is likely part of the reason it has garnered less attention, says Reshmi Srinath, an endocrinologist and director of the weight and metabolism program at Mount Sinai Health System