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The issue is usually temporary and not severe enough to become problematic

Loading phase (with neurological symptoms): 1mg on alternate days until there is no further improvement, then every two months

Some chemotherapy drugs or antiretroviral medications (for HIV) that suppress bone marrow might also blunt the effectiveness of B therapy

Some people who take high doses may experience some mild symptoms such as headache and nausea

Its always a good idea to watch for any unusual symptoms, like signs of infection, and contact your provider if you have any concerns