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It is well known that an enzyme simultaneously presented with two alternative substrates will catalyze their reactions in the ratio between their respective catalytic efficiency multiplied with the ambient substrate concentration, k cat /K m [substrate]

Likewise, no effect was observed on downstream components of the Insulin/IGF-1 signaling pathway with mAb treatment in females (Supplementary Fig 3), but L2-Cmu attenuated S6 activation in male hypothalamus (Supplementary Fig 4c

Adiponectin signaling suppresses vascular cell adhesion molecule-1 (VCAM-1) expression and maintains claudin-5 expression, whereas adiponectin deficiency exacerbates vascular leakage and endothelial inflammation (142144, 146)

RT-qPCR assay TRIzol Plus RNA Purification Kit (Invitrogen, Carlsbad, CA, USA) was used to perform total RNA extraction

By reducing oxidative stress, glutathione slows skin aging, marked by wrinkles, fine lines, and loss of elasticity

Linearity and sensitivity As shown in Fig