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doi: 10.3892/etm.2021.9637, 76

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Glutathione can not only be used in drugs, but also as a base material for functional foods

This modification orchestrates TME immunosuppression through dual mechanisms by suppressing effector immunity by impairing cytosolic DNA sensing via cGAS activity attenuation and amplifying TGF- signaling cascades in cytotoxic lymphocytes, while simultaneously enabling immune checkpoints by upregulating PD-L1 expression on antigen-presenting cells and stabilizing immunosuppressive Treg and TAM phenotypes (63)