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13.2 Animal Toxicology and/or Pharmacology Heart enlargement has been observed in mice (100 mg/kg), rats (4 mg/kg and above) and dogs (3 mg/kg) treated orally with pioglitazone (approximately 11, one, and two times the MRHD for mice, rats and dogs, respectively, based on mg/m2)

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Various cellular stresses, including oxidative stress, metabolic stress, and nutrient deprivation, initiate Ferroptosis

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[28] For children under the age of 18, safe levels of caffeine consumption have not been established