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Among the several AT 1 -R blockers available, candesartan (CAND) shows the tightest and longest-lasting binding to AT 1 -R (Unger, 2000)

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In fact, the use of GSTP1 knockout mice demonstrated that loss of GSTP1 expression increases sensitivity to metabolic or environmental toxins and promotes mutations and cancer development ( FIGURE 2 Prostate cancer Promoter hypermethylation leading to epigenetic silencing of GSTP1 gene expression is frequently detected in prostate cancer cells, the most commonly diagnosed type of malignancy among men in Western European countries and the second cause of cancer-related deaths among men worldwide (Jeronimo et al., 2002

Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement