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Oxidative Stress May Increase In animal models, sleep deprivation has been associated with a 2.5-fold increase in MDA (a marker of lipid peroxidation) and a 67% reduction in phosphatidylcholine, suggesting heightened oxidative injury and membrane damage (Chang et al., 2008

In the l-carnitine group, 35.4% (17/48) of patients had hyperammonemia at baseline