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Despite the complexity of TMAOs role in atherosclerosis, studies have indicated that managing TMAO through nutrition, medication, or microbiome modification may help lessen its effects and even reverse its contribution to the advancement of the disease [73, 76]
The risk of the primary outcome was 24% lower in all participants treated with semaglutide versus placebo (95% confidence interval: 34%, 12%)
It is a GLP-1 analogue that has undergone three modifications to extend its half-life, allowing for once-weekly administration ( Studies conducted as part of the Semaglutide Treatment Effect in People with Obesity (STEP) clinical trial development program evaluated the effects of a 2.4mg weekly dose of Semaglutide in overweight and obese individuals
A 2025 retrospective cohort study found that semaglutide was as effective for weight loss in people with IBD as it was for people without IBD
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