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Weirs, MD at The COEM Board-Certified Dr

While some oral and sublingual formulations exist, injection remains the gold standard with the most research support

Physical examination reveals tenderness over the A1 pulley with palpable nodularity

However, the absence of large-scale human trials, FDA approval, and standardized sourcing means that patients should proceed with caution

The inclusion criteria for the patients group consisted of mild to severe DE in in-patients aged 60 years with recurrent depressive disorder (RDD, F33.0-F33.3), bipolar disorder (BD, F31.3, F31.4), or single DE (F32.0-F32.2) by ICD-10

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