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A general pattern: Cardiovascular outcomes: semaglutide has stronger evidence Weight loss and glucose control: orforglipron is competitive and sometimes leads Convenience: orforglipron is simpler to use Medicare coverage If you have Medicare, you can get a pharmacy benefit card to buy Foundayo for $50 a month
Killion EA et al (2020) Glucose-Dependent Insulinotropic Polypeptide Receptor Therapies for the Treatment of Obesity, Do Agonists = Antagonists
& Datta, M
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Rouille, Y., Westermark, G., Martin, S
Retatrutide belongs to the next wave of research, but interest should be separated from approval
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