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Initiation requires documented impairment in quality of life, assessed using a validated tool such as the Assessment of Growth Hormone Deficiency in Adults (AGHDA) questionnaire, alongside evidence of pituitary disease or structural hypothalamic damage
Therefore, the results of ongoing CVD outcome trials with the use of GLP-1 RAs should be awaited to elucidate the translation of benefits previously seen in CVD risk marker studies into large clinical trials with primary cardiovascular outcomes
Presence of glutathione immunoreactivity in cultured neurones and astrocytes
A 2024 meta-analysis demonstrated comparable HbA1c and weight-reduction effects in adults 65 years and younger groups, though discontinuation due to adverse events was slightly higher [131]
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