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The Energy Molecule That Declines With Age Critically, endogenous CoQ10 synthesis declines progressively with age and is further depleted by the widespread use of statin medications (HMG-CoA reductase inhibitors), which are prescribed to a significant proportion of the elderly population for cardiovascular risk management

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Compared with other forms of cell death such as apoptosis, necrosis, and autophagy, ferroptosis exhibits distinct molecular mechanisms and biological features ( Table 1 ): (1) Iron Dependence: Ferroptosis is uniquely triggered by elevated intracellular iron levels, differentiating it from other cell death modes

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In adulthood, both mitochondrial fission and autophagosome markers, and OXPHOS complex I were increased, suggestive of increased energy demand and mitochondrial turnover