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Kassir R et al
[PMID: 3801053] PubMed record related to this compound for laboratory literature review
Abbreviations BCAAs: Branched-chain amino acids CIs: Confidence intervals DR: Dorsal raphe fMRI: Functional MRI GLP-1RAs: Glucagon-like peptide-1 receptor agonists GWAS: Genome-wide association studies IGF: Insulin-like growth factors IR: Insulin receptor IVW: Inverse-variance weighted LD: Linkage disequilibrium LIRA: Liraglutide LPS: Lipopolysaccharide MDD: Major depressive disorder MHC: Histocompatibility complex MR: Mendelian randomization OCD: Obsessive-compulsive disorder ORs: Odds ratios PGC: Psychiatric genomics consortium RCTs: Randomized controlled trials T2DM: Type 2 diabetes mellitus UKB: UK biobank References U.S
The initiation of oral GLP-1 RAs in patients within 1 year of T2D diagnosis resulted in robust HbA 1c and body weight reductions as well as attainment of glycaemic targets, including near-normal HbA 1c
The difference lies in direct bioavailability, allowing the chemical signal to reach the appropriate receptors without digestive interference
Following this, Thorens needed to verify its activity which he did by introducing the coding sequence into various cells
