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Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial [published correction appears in lancet

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Before that, multiple companies have encountered obstacles in their efforts to develop treatments for hyperphagia in Prader-Willi syndrome

The Short Answer GLP-1 medications do not cause disproportionate muscle loss compared to dieting alone

N Engl J Med (2020) 383(15):141324