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De Jong WH, Borm PJ (2008) Drug delivery and nanoparticles: applications and hazards
O., Bakos, H
In combination chemotherapy, drugs that are active against the tumor and have different toxicity profiles and mechanisms of action are used
Indeed, such abnormal presence of mitochondria in circulating red blood cells causes increased oxygen consumption, ROS generation, and hemolysis in SCD patients 50,51
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The incretin glucagon-like peptide-1 (GLP-1), released from the gut during food intake, amplifies glucose-stimulated insulin release by binding to and activating its cognate G protein-coupled receptor (GPCR), the GLP-1 receptor (GLP-1R), triggering cAMP generation and downstream Protein Kinase A (PKA) and Exchange Protein Activated by cyclic AMP 2 (Epac2) signalling 4 , a process that has been exploited to develop pharmacological GLP-1R agonists (GLP-1RAs) as T2D therapies
