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Liu Y, Krueger LD, Nguyen HP
Eder T, Weber A, Neuwirt H, Grunbacher G, Ploner C, Klocker H et al
Prolonged overdose of B6 (150-200 mg/day) over weeks can cause severe sensory-nervous-system dysfunction and ataxia.37 With normal usage serious adverse effects are not reported for pyridoxine (vitamin B6), however, diarrhoea, emesis and rosacea-like dermatitis may be observed in some cases (38)
As there is no meaningful expression of GLP-1 receptors on hepatocytes, the major effect of GLP-1 agonists on MASH is likely to be indirect and may be related to a reduction in calorie intake, body weight and insulin resistance, all of which would lead to reduced liver lipid accumulation and hepatic inflammation 7,8
GLP-1 receptor agonists bring a range of benefits for people managing type 2 diabetes alongside chronic kidney disease (CKD)
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