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Previously it has been shown that enhanced HR-type necrotization in TMV-infected NahG tobacco is indeed correlated to oxidative stress, as marked by the accumulation of ROS ( 1 hybrids that express nahG (CEMK-9 X NahG and TRI-2 X NahG F 1 ), wild type levels of TMV resistance (including HR necrosis) are coupled to hyperaccumulation of GSSG, an indication of constant suppression of oxidative stress in virus-infected plant cells

PLoS One, 9 (1), e85436

These regulatory subunits are identified as p40-PHOX, p47-PHOX, and p67-PHOX

PLoS ONE 10:e0126978

This can lead to completely skewed data, inflammatory responses in cell cultures, or unexpected molecular interactions

TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS