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We observed that AOAA treatment decreases cysteine and GSH levels while increases ROS and ferroptosis stresses in SCD erythroblasts (Supplementary Fig
From the perspective of signaling pathway regulation, DHRS7 may exert diverse effects by modulating key signaling pathways, such as EGF/EGFR, TGF-, IL-4, PI3K/AKT, and MAPK
It remains one of the few endogenous peptides whose receptor target has not been definitively characterized, making it an active subject of mechanism-of-action research
Ethics statement The animal study was reviewed and approved by the Animal Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology (HUST)
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