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Patients who lose weight gradually while monitoring muscle mass and body fat percentage typically experience less facial deterioration

EMBO Mol Med 15:EMMM202217052-

Quick Answer: Supplements to consider with tirzepatide include protein (to preserve muscle mass), vitamin B12, vitamin D, calcium, magnesium, omega-3 fatty acids, and fiber, though individual needs should be assessed by a healthcare provider rather than using supplements routinely

Adequate vitamin D supplementation does not ameliorate bone loss following long limb-biliopancreatic diversion in morbidly obese women

Based on human experiments, Holst hypothesized that GLP-1 caused slower emptying of the stomach, which sent a signal through the vagal nerve signifying fullness

2 Since it is non-peptide, orforglipron avoids GI degradation barriers that limit peptides, thereby enabling once-daily administration while maintaining efficacy on glucose control, body weight, and tolerability