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Gastrointestinal adverse effects, initially viewed as limiting, were ultimately managed through dose titration and formulation design
and establish strong compliance programs to ensure that the company, as a clinical trial sponsor, meets all quality system and other FDA requirements.
In landmark trials such as SUSTAIN-6 and PIONEER-6, semaglutide demonstrated a significant reduction in major adverse cardiovascular events, including cardiovascular death, non-fatal heart attacks, and strokes, compared to placebo or standard care