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Perhaps the closest he comes to this consideration might be his mention of nostril dilation in fearful horses, but he argues that this is the result of an association between fear and the exertions of rapid flight (Darwin, Reference Darwin1872: 130), rather than functioning to detect a source of danger

Franck M, Tanner KT, Tennyson RL, Daunizeau C, Ferrucci L, Bandinelli S, Trumble BC, Kaplan HS, Aronoff JE, Stieglitz J, Kraft TS, Lea AJ, Venkataraman VV, Wallace IJ, Lim YAL, Ng KS, Yeong JPS, Ho R, Lim X, Mehrjerd A, Charalambous EG, Aiello AE, Pawelec G, Franceschi C, Hertel J, Flp T, Lemoine M, Gurven M, Cohen AA (2025) Nonuniversality of inflammaging across human populations

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As a result, those molecules also turn into free radicals leading to a snowball effect that can disrupt a cells integrity, causing it to behave abnormally

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