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16 GLP-1RAs achieve sustained pharmacological effects by resisting degradation by DPP-4 in the body, consequently contributing to hyperglycemia and insulin resistance related to glucose metabolism, 17,18 lipid profile alterations, changes in fat composition, visceral fat accumulation, and obesity related to lipid metabolism, 1921 which constitute the systemic metabolic characteristics of interest in MASLD management

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The mechanism of action involves several physiological effects: Enhanced insulin secretion : GLP-1 agonists stimulate glucose-dependent insulin release from pancreatic beta cells, helping to lower blood glucose levels without causing hypoglycaemia when glucose levels are normal