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The activation of the costimulatory receptor CD28 induces PDE4, resulting in the hydrolysis of cAMP, the induction of NF-B, activator protein-1 (AP-1) and NFAT, as well as the activation and proliferation of T cells
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Microbiologyopen 8 , e927 (2019)
Even with such a large contact area, capillary ECs in the CNS, unlike those in most peripheral organs, lack small pores that would allow polar solutes to pass through the barrier because of the presence of tight junctions (TJs)
All three methods are effective, but all three also have significant and therapy-specific side effects
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