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Copper Ion Accumulation Risk GHK-Cu Copper Tripeptide-1 Powder exerts its biological activity by chelating copper ions at a 1:1 ratio

This combination is particularly relevant for patients presenting with acne scarring, skin laxity, or texture irregularities in South Floridas Fitzpatrick III through VI population

Free Cu2+ is toxic (Fenton reactions, hydroxyl radicals), but the GHK-Cu complex is stable, diffusible and delivers copper in a targeted manner to copper-dependent metalloenzymes: lysyl oxidase (collagen/elastin crosslinking), Cu/Zn superoxide dismutase (SOD1, antioxidant defence), tyrosinase (controlled melanogenesis), dopamine-beta-hydroxylase

PMCID: PMC11890406

While this sounds encouraging, we must recognize this was not a controlled trial there was no placebo group, and the patients (and doctors) knew they were receiving the peptide

We evaluated the pH stability of D-CuP across the range of cutaneous wound conditions (pH 49)