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These sex differences have biological plausibility because GLP-1 receptors are expressed in central appetite circuits and peripheral tissues whose signaling is modulated by estrogen and other sex steroids (Vigil et al., 2022
Recent trial data demonstrate that these benefits extend to individuals without diabetes, underscoring their role as cardiometabolic therapies rather than purely glucose-lowering medications [50, 51]
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Super interesting topic
Ozempic (semaglutide) and Mounjaro (tirzepatide) These are FDA approved for type 2 diabetes, not for weight loss
Notably, resveratrols paradoxical pro-oxidant behavior in copper-rich environments drives selective DNA cleavage through ternary complex formation (DNA-resveratrol-Cu(II)), inducing double-strand breaks that are poorly repaired in malignant cells [118]
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