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Introduction Glucagon-like peptide-1 (GLP-1), a neuroendocrine hormone, is derived from a proglucagon precursor1 and secreted by intestinal enteroendocrine L cells in response to nutrient intake, predominantly in the form of GLP-1(736) amide (henceforth GLP-1)
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In addition, obesity could inhibit hepatic utilization of BCAAs and cause the inactivation of BCKDH by increasing the ratio of BCKDK (BCKDH kinase)/PPM1K (BCKDH dephosphorylase) in hepatocytes
Pivotal Phase 3 trials Trial SURMOUNT-1 (NEJM 2022) Population 2,539 adults, obesity, no diabetes
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