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If reticulocytes have not increased after treatment or if reticulocyte counts do not continue at least twice normal as long as the hematocrit is less than 35%, diagnosis or treatment should be reevaluated
All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA)
The TEM (FEI Tecnai G2 F30, Netherlands) and scanning electron microscope (SEM, Regulus 8230, Japan) were employed to observe the appearance and detect the elemental composition of the SeC@PA, respectively
Second, evaluate timing conflicts