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Normalization of raw counts and subsequent calculation of differential gene expression was performed with DESeq2 package (version 1.46.0) [32] for R (version 4.4.1) with default parameters

Collectively, the results discussed above could be interpreted to suggest that conditions likely to result in -cell stress, such as obesity, hyperglycaemia, and inflammation, activate compensatory responses in an attempt to improve -cell function and survival

The brain becomes more sensitive to hunger cues

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