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The SURMOUNT-1 clinical trial showed that participants on 15 mg of tirzepatide lost an average of 22.5% of their body weight over 72 weeks

Expected timelines put the semaglutide patent cliff in the early 2030s and the tirzepatide cliff in the early-to-mid 2030s

However, both can affect appetite, mood, and gastrointestinal function, which may influence tolerability when taken together

Why NSAIDs May Worsen Chronic Pain Over Time When gut integrity is compromised and nutrient absorption declines, inflammatory signaling becomes harder to regulate

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