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Unresolved hypotheses: mechanistic proposals that remain plausible but have not been directly demonstrated in the relevant AOD9604 metabolic model

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The resulting increase in intracellular NAD+ availability activates sirtuins particularly SIRT1, which regulates insulin sensitivity, gluconeogenesis, cholesterol synthesis, and fatty acid oxidation, and SIRT3, which governs mitochondrial antioxidant defences and energy metabolism

However, this is often just moderate and will pass fast

What does this mean for weight loss