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GLP-1(7-37) significantly stimulated insulin secretion, suggesting it plays an important role in insulin secretion (Mojsov et al 1987)

GLP-1 is an incretin, a group of hormones that stimulate a decrease in blood glucose levels

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These older GLP-1 drugs remain in use but have been largely overtaken by semaglutide and tirzepatide in new prescriptions

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They are released throughout the day, increasing at mealtimes, and have several functions: Stimulate the production and secretion of insulin in response to eating (glucose-dependent insulin secretion) GLP-1 enhances the sensitivity of alpha cells to glucose, resulting in more glucose-appropriate glucagon secretion Slow digestion and decrease appetite Thus, DPP-4 inhibitors indirectly enhance insulin release, suppress glucagon secretion, and improve glycaemic control