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However, up to 40% of patients do not achieve satisfactory relief, prompting investigation of combination therapy, most commonly adding a second agent (e.g., duloxetine plus pregabalin), which can yield incremental pain reduction of 1020% but with increased risk of sedation, dizziness and drug interactions [64]

This phase 3 global registration study involved 2,539 participants and met its primary endpoints for both mean percent change in body weight and the percentage of participants achieving 5% body weight reductions