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A desthiobiotin labelled NAD(+) analogue to uncover Poly(ADP-ribose) polymerase 1 protein targets

(1) It can be used as an adjuvant therapy for chemotherapy (cisplatin, cyclophosphamide, doxorubicin, daunorubicin, bleomycin) to reduce chemotherapy-induced damage without affecting efficacy, thereby allowing for an increase in chemotherapy dosage

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However, under pathological conditions, iron is readily involved a single electron transfer reaction and is transformed into ferrous iron, which shows high reactivity and toxicity

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