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Out-of-spec pH (too acidic or too alkaline) accelerates hydrolysis of Asp-Pro and Asp-Gly bonds

Additionally, GH receptor (GHR) is widely expressed in hypothalamic areas implicated in energy balance regulation, including the arcuate nucleus (ARH) 11

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Indeed it consists of two transmembrane domains, a large extracellular domain, and two short intracellular domains that are required for CD36 function after substrate binding (Su and Abumrad, 2009)