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During the dose escalation phasetypically the first 1216 weeks of treatmentyour body is adjusting to tirzepatide's effects on digestion, appetite, and metabolism

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Karg MV, Bosch A, Kannenkeril D, Striepe K, Ott C, Schneider MP, Boemke-Zelch F, Linz P, Nagel AM, Titze J, Uder M, Schmieder RE

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The recommended dose typically ranges between 500 mg and 2,000 mg per day, taken approximately 30 minutes before physical activity

In both trials, 75% of participants had HFpEF (ejection fraction 50%), and 25% had HF with mildly reduced ejection fraction (ejection fraction 45%-49%)