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Himmelstein MS, Puhl RM, Quinn DM
Long-term safety, tolerability, and weight loss associated with metformin in the diabetes prevention program outcomes study
Tight junctions between intestinal epithelial cells restrict paracellular transport to molecules with radii well below those of therapeutic peptides, while transcellular transport favors lipophilic small molecules rather than hydrophilic macromolecules (Lundquist and Artursson, 2016)
Some of these changes can cause stronger body odors, including in urine
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