(Weinheim: Wiley-VCH Verlag GmbH & Co), 389419
At this stage, pyramidal neurons have as many as 7,000 spines, which can form elaborate patterns
While the clinical impact of GLP-1s on approved indications (e.g., obesity, diabetes, cardiovascular risk) and adjacent indications is being studied extensively in clinical trials, there is limited scientific literature on GLP-1 use, efficacy or persistence outside of clinical trial settings
Kepka A, Ochocinska A, Borzym-Kluczyk M, Skorupa E, Stasiewicz-Jarocka B, Chojnowska S, Waszkiewicz N (2020) Preventive role of L-carnitine and balanced diet in alzheimer's disease
Its GLP-1 activity is important, but it does not fully explain the compounds pharmacologic profile
Therefore, a better understanding of the dysregulation of the antioxidant KEAP1-NRF2 activity in ALS could help to develop novel therapeutic strategies able to halt disease progression, prolonging patients survival