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Clinical trials generally do not charge participants for the investigational study drug, but details vary by protocol and site
The FDA approved tirzepatide under the brand name Zepbound for chronic weight management in adults with obesity or overweight with at least one weight-related condition, alongside a reduced-calorie diet and increased physical activity
Some individuals notice mild water retention during the first week
Infants less than 1 year old should get 50 milligrams (mg) per day
However, GLP-1s accounted for over 8% of all Medicaid prescription drug spending before rebates in 2024 (up from 1% in 2019)
For those using GLP-1 medications for weight management, reduced efficacy may manifest as weight loss plateau or regain
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