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Furthermore, GPX2 is a downstream target of NRF2 [33] and is considered a potential target for overcoming chemoresistance [38, 49]
HYR HYdroperoxide Resistance
Differentiating Changes in Glutathione Levels from Cytotoxic Events Using Multiplexed Assays Alisha Truman and Brad Hook Promega Corporation Publication Date: October 2013 Abstract Measuring changes in glutathione levels as a single endpoint may not be sufficiently informative to differentiate a decrease in GSH from a cytotoxic event
S., Marshall, A
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This 85% rate was not a historical control derived from rates of sustained virologic response in prior HCV treatment trials, since it would not be possible to calculate a single historical rate for the different standard treatments recommended for the various genotypes included in this study
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