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Most people who persist through the initial adjustment periods achieve substantial weight loss that makes the temporary discomfort worthwhile
This slow and steady approach to weight loss is generally seen as healthier and more sustainable because it helps people keep the weight off for the long term
With respect to therapeutic implications, GDF15 has been shown to reduce the lipogenic arm of the glycerolipid cycle in adipose tissue (387), and mouse and human studies show that inhibition of GDF15 with monoclonal antibodies reverses cancer cachexia (299, 382)
Whats actually happening is a biological response to undereating
Lee et al., 2021)
In the STEP 1 trial, average weight loss on Wegovy 2.4 mg was 14.9% over 68 weeks, with 86% of participants achieving at least 5% weight loss and around half reaching at least 15%
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